04 73 40 54 27
04 73 40 79 63
design, molecular modelling, chemical synthesis, extraction, natural products, aromatics,
ACTIVITES DE RECHERCHE / SERVICES
The team « Organic and Medicinal Chemistry « brings together an ensemble of expertise ranging from the design of original synthetic molecules by Molecular Modelling to the full achievement and characterization of the target molecules. The projects which are developed sit at the interface between chemistry and biology, with a particular focus on projects that have a link to cancer .
In particular the team COM is interested by the design and synthesis of heteroaromatic compounds (Indoles, Quinolines, Indazoles, Pyrimidines…) with protein kinases (Pim, DYRK1A, CLK1…) inhibitory potencies. The design and synthesis of folded peptide mimetics for mediation or inhibition of protein-protein interactions involved in apoptosis (biotic and abiotic helical BH3-domain mimetics as selective inhibitors of anti-apoptotic proteins) is also studied. In the context of anticancer immunotherapy, carbohydrate-based tumor-associated anticancer vaccine conjugates have also been conceived. The team has been developping vascular-disrupting agents (VDA) to target tumor angiogenesis. The extraction of plants to identify natural products with anticancer activity is also of interest.
COMPETENCES / MOYENS TECHNIQUES
- ICCF Chemical library, member of the French National Chemical Library (GIS « Chimiothèque Nationale.
- Facilities such as mass spectrometry, NMR and X-ray diffraction are available from UCA Partner
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UMR CNRS 6296 Insitute of Chemistry of Clermont-Ferrand (ICCF)
Campus Universitaire des Cézeaux, 24 avenue Blaise Pascal