|Marie-Odile Fauvarque |
Cancer, Cell signaling, Cell trafficking, Drug screening, Endocytosis, Inflammation, Rare disease, Screening for Bioactive Molecules, Ubiquitin system, Ubiquitin specific protease (USP) Therapeutic targets
ACTIVITES DE RECHERCHE / SERVICES
The Gen&Chem team develops genetics and chemogenomics approaches for the study and targeting of proteins regulating cell signaling and trafficking. The team includes molecular geneticists dedicated to the acquisition of fundamental knowledge and the CMBA screening platform dedicated to Drug Discovery, i.e : to the identification of bioactive molecules valuable for both research and therapeutic purposes. This association aimed at mutually benefit from complementary expertise to strengthen both kind of activities and promotes translational research.
The research activity notably aims to provide fundamental insights into the role of the ubiquitin system in signal transduction and endocytosis of plasma membrane receptors (such as the EGFR or TNFR) that provide appropriate cellular responses to cell growth or differentiation signals. Special attention is given to deubiquitinating enzymes (DUBs) of the ubiquitin-specific protease subfamily that regulate membrane receptor trafficking and downstream intracellular signaling cascades. These DUBs are known therapeutic targets in several pathologies, including chronic inflammation, cancer or rare diseases but their substrates and mechanisms of action are still poorly known.
COMPETENCES / MOYENS TECHNIQUES
The research of the team is based on the implementation of molecular genetics, transgenesis, mutagenesis and cell biology strategies on murine or Drosophila fly models.
The screening platform for bioactive molecules (CMBA) is fully equipped to perform high-throughput screening campaigns (HTS) on either purified targets or living cells, including phenotypic screening by automated imaging using the high content screening methodology (HCS) (see also the dedicated form of CMBA platform).
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UMRS_1038 Large Scale Laboratory (BGE)
17 rue des Martyrs