Small Molecules for Biological Targets

CHAMPS D’EXPERTISE

Fragment screening and Drug screening against soluble and membrane proteins, structural characterization of protein-small molecule interactions, affinity measurements, Bio-Layer Interférométrie,  chemical synthesys, medicinal chemistry, cell assays

ACTIVITES DE RECHERCHE / SERVICES

The team project is dedicated to the development of small molecules targeting biological targets of interest, including soluble as well as membrane proteins such as the GPCR family of proteins. The team mainly focuses its research in the generation of compounds capable to bind binding sites different from orthosteric/active site as the allosteric sites and protein-protein interaction sites. In this context, one of the team objectives is the development of “linked” or “bivalent” compounds. All activities of the team can be provided as collaborations or services for academic and privates groups.

COMPETENCES / MOYENS TECHNIQUES?

The team activity includes hit identification through fragment-based approaches, characterization of protein-small molecules complexes (structural investigation, affinity mesaurement) and hit-to lead optimization based on structural and medicinal chemistry skills.
• Structural characterization of protein-ligand complexes using NMR (the platerform at CRMN is opned for collaborations or services for academic groups as well as private compagnies)
• Biophysical characterization of protein-ligand complexes
• Chemical synthesys and medicinal chemistry
• Libraries : a non-focused fragment library and a kinase-focused library

OU NOUS TROUVER ?

Centre de RMN à très haut champ de Lyon
Centre de Recherche en Cancérologie de Lyon
5 rue de la Doua 69100 Villeurbanne
8 avenue Rockefeller 69008 Lyon